RepliFit

Toolkit for analyzing DNA replication timing, origin firing rates, and genomic stability.

We introduce RepliFit, a comprehensive toolkit for analysing DNA replication timing, origin firing rates, and genomic stability across cell lines and chromosomal regions. It includes functions for loading and processing data across whole-genome regions, telomeres, centromeres, and specific loci of interest. By fitting origin firing rates to replication timing data, the toolkit efficiently predicts and compares experimental and modelled timing profiles . The resulting error distributions between predicted and experimental data help in pinpointing regions of interest.

Fitting Repi-seq timing data with a stochastic model of replication.

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