Introducing a new multi-layer model to predict cell development!

Our new preprint is out! 🎉

We show how the complex 3D shapes of epithelial cells in the Drosophila wing can expand their network of neighbours to fine-tune Notch–Delta signalling and achieve precise cell patterning. Using a new mathematical framework, the Multi-layer Signalling Model, we link real 3D cell topologies to signalling range, and confirm predictions with in vivo experiments.

🔗 Read the full paper here: doi.org/10.1101/2025.08.08.668674

A big thank you to my co-authors Giulia Paci, Yanlan Mao, Karen M. Page, Buzz Baum, and everyone who supported this research.